Technology
Precision Microbiome Profiling (PMP™)
A high-throughput microbiome analysis platform with the features required for routine clinical applications — enabling rapid, accurate and actionable analysis of the gut, skin and vaginal microbiomes.
The platform
Targeted qPCR on OpenArray®
PMP™ is a qPCR-based approach on Thermo Fisher Scientific’s OpenArray® platform. It delivers accurate and detailed information about the microbiome in a high-throughput format, readily available for interpretation and in a faster timeframe than traditional microbiome analysis approaches.
Highly parallelised qPCR enables quantitative detection of many microbes simultaneously, making it possible to analyse hundreds of samples in less than a day.
Assay design pipeline
Target selection and assay development
At the heart of our technology is the assay design pipeline, with thorough in silico and wet-lab validation.
- Step 1
Target selection
Each microbial target is carefully selected for prevalence, abundance and physiological relevance.
- Step 2
In silico design
Assays are designed and checked computationally for specificity.
- Step 3
Wet-lab validation
Each assay is validated in the laboratory to be highly specific and true-to-target.
- Step 4
Panels
Validated assays are combined into panels of highly relevant targets for reliable, reproducible profiling.
Unique biobank access
Collaboration with HUNT4
Through a special collaboration with HUNT4, a large-scale population-based observational cohort, Bio-Me has access to fecal samples from 13,300 individuals and their anonymised medical registries with more than 6,000 different health parameters. This enables microbiome discovery of novel biomarkers and drug targets.
Let’s discuss your microbiome project.
Tell us about your research question, application or analysis needs.